Treatment for Parkinson’s disease
The main aim of cure is to ease symptoms and keep the patient functional as long as achievable. Because Parkinson’s disease has no cure, Treatment consists of drugs, substantial therapy and, in severe disease states unmoved to drugs, stereotactic neurosurgery or the controversial treatment called fetal cell transplantation. In this cure, fetal brain tissue is injected into the patient’s brain.,They will allow the brain to process dopamine, thereby either halting or reversing disease progression. Neurotransplantation techniques, including the use of nerve cells from other parts of the patient’s body, have been attempted with unreliable outcome if the injected cells grow within the recipient’s brain
During early stages we see drug therapy generally includes levodopa, a dopamine substitution that’s most effective. It’s given in rising doses until symptoms are relieved or adverse effects appear., levodopa is frequently given in combination with carbidopa to halt peripheral dopamine synthesis because adverse effects can be serious. Occasionally, levodopa proves unsuccessful, producing dangerous adverse effects that include postural hypotension, hallucinations, and increased libido leading to inappropriate sexual behavior. Drug therapy includes anticholinergics such as trihexyphenidyl, antihistamines such as diphenhydramine, and amantadine, an antiviral agent is included in that case. Research on the oxidative stress theory has been a reason for a controversy in drug therapy for Parkinson’s disease. Usually, levodopa-carbidopa has been a first-line drug in management; however, it has also been linked with an acceleration of disease process. Inclusion of entacapone potentiates the effects of levodopa-carbidopa treatment so that less frequent doses are required.
Selegiline, an enzyme-inhibiting agent, allows storing up of dopamine and enhances the therapeutic effect of levodopa. Selegiline used with tocopherols delays the time when the patient with Parkinson’s disease becomes disabled.
