On the presence of central nervous system (CNS) lesions that are disseminated in time and space (i.e., occur in different parts of the CNS at least three months apart), with no better explanation for the disease process the diagnosis of MS is based. Because no single test is totally reliable in identifying MS, and a variety of conditions can mimic the disease
Magnetic resonance imaging (MRI) has been shown to be highly sensitive in detecting clinically silent MS plaques. Findings of this imaging Consequently, modality are included in diagnostic criteria that have been proposed by one set of investigators.1 The major advantage of the planned criteria is that an early diagnosis of MS can be made if an MRI scan performed three months after a clinically isolated attack demonstrates formation of a new lesion. Including number of lesions (nine or more), location of lesions (position abutting the ventricles; juxtacortical, infratentorial, or spinal position), and lesion enhancement with the use of contrast medium The proposed diagnostic criteria also define MRI lesion characteristics that increase the likelihood of MS.
