Radical nephrectomy, with or lacking of regional lymph node dissection, offers the only possibility of treatment. Because the disease is radiation resistant, radiation is used only if the cancer spreads to the perinephric region or the lymph nodes or if the primary tumor or metastatic sites can’t be completely excised.

In this case, high radiation doses are used. Chemotherapy has been only erratically effectual beside kidney cancer. Fluorouracil, cyclophosphamide, vinblastine, vincristine, cisplatin, tamoxifen, teniposide, interferons, and hormones for example medroxyprogesterone and testosterone have been used, generally with poor results. Biotherapy (interferon and interleukins), commonly used in advanced disease, has produced few durable diminution.